What are SGLT-2 Inhibitors
Patients with type 2 diabetes can take SGLT-2 inhibitors orally. SGLT-2 represents sodium-glucose cotransporter-2, a protein responsible for kidney glucose reabsorption. SGLT-2 inhibitors work by blocking this protein, which prevents glucose reabsorption. It leads to increased glucose excretion in the urine. By increasing urinary glucose excretion, SGLT-2 inhibitors help to lower blood glucose levels and improve glycemic control in patients with type 2 diabetes.
In addition to their glucose-lowering effects, SGLT-2 inhibitors provide other beneficial effects, including:
- Weight Loss: SGLT-2 inhibitors are associated with modest weight loss in patients with type 2 diabetes.
- Blood Pressure Reduction: SGLT-2 inhibitors are known to reduce blood pressure in patients with type 2 diabetes, which may help reduce the risk of cardiovascular complications.
- Renal Protection: SGLT-2 inhibitors reduce the risk of kidney disease progression in patients with type 2 diabetes.
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| SGLT-2 Inhibitors for type 2 diabetes |
What are the advantages of SGLT-2 inhibitors?
- Glucose-Lowering Effects: SGLT-2 inhibitors lower blood glucose levels in patients with type 2 diabetes. SGLT-2 inhibitors block glucose reabsorption in the kidneys, and SGLT-2 inhibitors increase glucose excretion in the urine, leading to lower blood glucose levels.
- Weight Loss: SGLT-2 inhibitors interconnect with modest weight loss in patients with type 2 diabetes. This beneficial process controls overweight or obese patients, as weight loss can improve insulin sensitivity and glucose control.
- Blood Pressure Control: SGLT-2 inhibitors reduce blood pressure in patients with type 2 diabetes. This action can be particularly beneficial for patients with hypertension, as high blood pressure is a risk factor for cardiovascular disease.
- Cardiovascular Benefits: SGLT-2 inhibitors reduce the risk of cardiovascular events, such as heart attack and stroke, in patients with type 2 diabetes who have established cardiovascular disease or are at high risk for cardiovascular disease.
- Renal Protection: SGLT-2 inhibitors reduce the risk of kidney disease progression in patients with type 2 diabetes. This process is significant, as kidney disease is a common complication of diabetes and can lead to morbidity and mortality.
- Canagliflozin
- Dapagliflozin
- Empagliflozin
- Ertugliflozin
- Ipragliflozin
- Luseogliflozin
- Urinary tract infections
- Genital yeast infections
- Increased urination
- Dehydration
- Low blood pressure
- Dizziness
- Fatigue
- Increased cholesterol levels
- Increased risk of fractures
- Ketoacidosis (a condition that can occur when there is too much acid in the blood)
- Acute kidney injury
- Fournier's gangrene (a rare but serious bacterial infection of the genital area)
- Lower limb amputations become more likely
- Increased risk of bone fractures
- probability of cardiovascular complications including heart attacks and stroke rising
Some common examples of SGLT-2 inhibitors include canagliflozin, dapagliflozin, and empagliflozin. While generally well-tolerated, SGLT-2 inhibitors can have side effects such as an increased risk of urinary tract infections, genital infections, and dehydration.
Diabetologists prescribe SGLT-2 inhibitors in combination with other medications and lifestyle changes as part of a comprehensive treatment plan for type 2 diabetes.
SGLT-2 inhibitors offer several advantages for the management of type 2 diabetes:
Overall, SGLT-2 inhibitors offer several benefits for type 2 diabetes and may be particularly useful for patients with multiple risk factors for cardiovascular ailment and kidney disease. However, like all medications, they have potential side effects and should be used under the guidance of a diabetologist.
SGLT2 inhibitors are a class of oral medications used for type 2 diabetes. There are currently several different types of SGLT2 inhibitors available on the market, including:
These medications work by blocking the action of the SGLT2 protein in the kidneys, which is responsible for reabsorbing glucose from the urine back into the bloodstream. SGLT2 inhibitors are protein blocks that help people with type 2 diabetes lower their blood glucose levels.
Like all medications, SGLT2 inhibitors have potential risks and side effects. Some of the common side effects that may occur with the use of SGLT2 inhibitors include:
Some of the risks associated with SGLT2 inhibitors include
It's important to note that not everyone who takes SGLT2 inhibitors will experience these side effects or risks, and many people can take these medications safely with minimal side effects. You can speak with your healthcare provider if you have concerns about a new medicine.
SGLT2 inhibitors help people with type 2 diabetes regulate their blood sugar levels. This drug helps with heart failure, cardiovascular disorders, and renal disease. SGLT2 inhibitors can lower blood sugar levels. SGLT2 inhibitors are safe but can have adverse effects or interact negatively with other medications. Your doctor can provide further information about the possible advantages and dangers of including this drug in your treatment plan.